Boxed Warning
Cardiomyopathy:
Doxorubicin (liposomal) can cause myocardial damage, including acute left ventricular failure. The risk of cardiomyopathy was 11% when the cumulative anthracycline dose was between 450 and 550 mg/m2. Assess left ventricular cardiac function prior to initiation of doxorubicin (liposomal) and during and after treatment.
Infusion-related reactions:
Serious, life-threatening, and fatal infusion-related reactions can occur with doxorubicin (liposomal). Acute infusion-related reactions occurred in 11% of patients with solid tumors. Withhold doxorubicin (liposomal) for infusion-related reactions and resume at a reduced rate. Discontinue doxorubicin (liposomal) for serious or life-threatening infusion-related reactions.
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Injectable, Intravenous, as hydrochloride:
Doxil: 2 mg/mL (10 mL, 25 mL)
Lipodox 50: 2 mg/mL (25 mL [DSC])
Generic: 2 mg/mL (10 mL, 25 mL)
Injectable, Intravenous, as hydrochloride [preservative free]:
Generic: 2 mg/mL (10 mL, 25 mL)
Pharmacology
Mechanism of Action
Doxorubicin inhibits DNA and RNA synthesis by intercalating between DNA base pairs causing steric obstruction and inhibits topoisomerase-II at the point of DNA cleavage. Doxorubicin is also a powerful iron chelator. The iron-doxorubicin complex can bind DNA and cell membranes, producing free hydroxyl (OH) radicals that cleave DNA and cell membranes. Active throughout entire cell cycle. Doxorubicin liposomal is a pegylated formulation which protects the liposomes, and thereby increases blood circulation time.
Pharmacokinetics/Pharmacodynamics
Distribution
Vdss: ~2.7 to 2.8 L/m2; largely confined to vascular fluid
Metabolism
Hepatic and in plasma to doxorubicinol and the sulfate and glucuronide conjugates of 4-demethyl,7-deoxyaglycones
Half-Life Elimination
Terminal: Distribution: ~4.7 to 5.2 hours, Elimination: ~52 to 55 hours
Protein Binding
Unknown; nonliposomal (conventional) doxorubicin: ~70%
Use: Labeled Indications
AIDS-related Kaposi sarcoma: Treatment of AIDS-related Kaposi sarcoma (after failure of or intolerance to prior systemic therapy)
Multiple myeloma: Treatment of multiple myeloma (in combination with bortezomib) in patients who are bortezomib-naïve and have received at least 1 prior therapy
Ovarian cancer, advanced: Treatment of progressive or recurrent ovarian cancer (after platinum-based treatment)
Use: Off Label
Breast cancer, metastatica
Data from a large randomized trial comparing doxorubicin liposomal with commonly used salvage regimens in patients with taxane-refractory metastatic breast cancer supports its use in this patient population Keller 2004.
Hodgkin lymphoma (salvage treatment)b
Data from a phase I/II trial supports the use of doxorubicin liposomal (in combination with gemcitabine and vinorelbine) in the treatment of relapsed Hodgkin lymphoma Bartlett 2007. Additional trials may be necessary to further define the role of doxorubicin liposomal in this condition.
Cutaneous T-cell lymphomas (mycosis fungoides and Sézary syndrome)b
Data from a phase II trial supports the use of doxorubicin liposomal in the treatment of mycosis fungoides Dummer 2012. In addition, a small retrospective analysis also suggests that doxorubicin liposomal is beneficial in cutaneous T-cell lymphomas Wollina 2003.
Soft tissue sarcomas, advancedb
Data from a randomized phase II study comparing doxorubicin liposomal to conventional doxorubicin suggests that the liposomal product may be beneficial in the treatment of patients with advanced soft tissue sarcomas Judson 2001.
Uterine sarcoma, advanced or recurrentb
Data from a small phase II trial suggest that liposomal doxorubicin may be beneficial in the management of advanced or recurrent uterine leiomyosarcoma Sutton 2005.
Contraindications
Severe hypersensitivity (including anaphylaxis) to doxorubicin liposomal, conventional doxorubicin, or any component of the formulation
Canadian labeling: Additional contraindications (not in the US labeling): Breast-feeding
Dosage and Administration
Dosing: Adult
Liposomal formulations of doxorubicin should NOT be substituted for conventional doxorubicin hydrochloride on a mg-per-mg basis.
AIDS-related Kaposi sarcoma: IV: 20 mg/m2 once every 21 days until disease progression or unacceptable toxicity
Multiple myeloma: IV: 30 mg/m2 on day 4 every 21 days (in combination with bortezomib) for 8 cycles or until disease progression or unacceptable toxicity (Orlowski 2007)
Multiple myeloma, newly diagnosed (off-label dosing): IV: 40 mg/m2 on day 1 every 4 weeks (in combination with vincristine and dexamethasone) for at least 4 cycles (Rifkin 2006).
Ovarian cancer, advanced: IV: 50 mg/m2 once every 28 days until disease progression or unacceptable toxicity
Ovarian cancer, advanced, recurrent (off- label dosing): IV: 40 mg/m2 once every 28 days (as a single agent) until disease progression or unacceptable toxicity (Ferrandina 2008; Rose 2001) or 30 mg/m2 once every 28 days (in combination with carboplatin) for at least 6 cycles (Pujade-Lauraine 2010) or 40 mg/m2 once every 28 days (in combination with bevacizumab) until disease progression or unacceptable toxicity (Pujade-Lauraine 2014).
Breast cancer, metastatic (off-label use): IV: 50 mg/m2 every 4 weeks (Keller 2004)
Cutaneous T-cell lymphomas (off-label use): IV: 20 mg/m2 days 1 and 15 every 4 weeks for 6 cycles (Dummer 2012) or 20 mg/m2 every 4 weeks (Wollina 2003)
Hodgkin lymphoma, salvage treatment (off-label use): IV: GVD regimen: 10 mg/m2 (post-transplant patients) or 15 mg/m2 (transplant-naive patients) days 1 and 8 every 3 weeks (in combination with gemcitabine and vinorelbine) for 2 to 6 cycles (Bartlett 2007)
Soft tissue sarcoma, advanced (off-label use): IV: 50 mg/m2 every 4 weeks for 6 cycles (Judson 2001)
Uterine sarcoma, advanced or recurrent (off-label use): IV: 50 mg/m2 every 4 weeks until disease progression or unacceptable toxicity (Sutton 2005)
Dosing: Geriatric
Refer to adult dosing.
Dosing: Adjustment for Toxicity
US labeling: Note: Once a dosage reduction due to toxicity has been implemented, the dose should not be increased at a later time.
Hematologic toxicity:
AIDS-related Kaposi sarcoma and ovarian cancer:
Grade 1 (ANC 1,500 to 1,900/mm3or platelets 75,000 to 150,000/mm3): No dosage adjustment necessary.
Grade 2 (ANC 1,000 to <1,500/mm3or platelets 50,000 to <75,000/mm3): Delay treatment until ANC ≥1,500/mm3 and platelets ≥75,000/mm3; resume treatment at previous dose.
Grade 3 (ANC 500 to 999/mm3 or platelets 25,000 to <50,000/mm3): Delay treatment until ANC ≥1,500/mm3 and platelets ≥75,000/mm3; resume treatment at previous dose.
Grade 4 (ANC <500/mm3 or platelets <25,000/mm3): Delay treatment until ANC ≥1,500/mm3 and platelets ≥75,000/mm3; then resume at 25% dose reduction or continue at previous dose with granulocyte growth factor support.
Multiple myeloma (in combination with Bortezomib) (see Bortezomib monograph for bortezomib dosage reduction with toxicity guidelines):
Fever ≥38°C and ANC <1,000/mm3: If prior to doxorubicin liposomal treatment (day 4), do not administer (withhold); if after doxorubicin liposomal administered, reduce dose by 25% in next cycle.
ANC <500/mm3, platelets <25,000/mm3, hemoglobin <8 g/dL: If prior to doxorubicin liposomal treatment (day 4); do not administer (withhold); if after doxorubicin liposomal administered and if bortezomib dose reduction occurred for hematologic toxicity, reduce dose by 25% in next cycle
Nonhematologic toxicity:
Hand-foot syndrome (HFS):
Grade 1 (mild erythema, swelling, or desquamation not interfering with daily activities): If no prior grade 3 or 4 HFS toxicity, no dosage adjustment is necessary. If prior grade 3 or 4 HFS toxicity, delay dose up to 2 weeks and decrease dose by 25%.
Grade 2 (erythema, desquamation, or swelling interfering with, but not precluding, normal physical activities; small blisters or ulcerations <2 cm in diameter): Delay dosing up to 2 weeks or until resolved to grade 0 or 1. If after 2 weeks there is no resolution, discontinue liposomal doxorubicin. If resolved to grade 0 or 1 within 2 weeks and no prior grade 3 or 4 HFS, continue treatment at previous dose. If a prior grade 3 or 4 HFS has occurred, decrease dose by 25%.
Grade 3 (blistering, ulceration, or swelling interfering with walking or normal daily activities; cannot wear regular clothing): Delay dosing up to 2 weeks or until resolved to grade 0 or 1, then decrease dose by 25%. If no resolution after 2 weeks, discontinue liposomal doxorubicin.
Grade 4 (diffuse or local process causing infectious complications, or a bedridden state or hospitalization): Delay dosing up to 2 weeks or until resolved to grade 0 or 1, then decrease dose by 25%. If no resolution after 2 weeks, discontinue liposomal doxorubicin.
Infusion reaction: Temporarily stop infusion until resolution and then resume at a reduced rate. For serious or life threatening reaction, discontinue infusion.
Stomatitis:
Grade 1 (painless ulcers, erythema, or mild soreness): If no prior grade 3 or 4 toxicity, no dosage adjustment is necessary. If prior grade 3 or 4 toxicity, delay dose up to 2 weeks and decrease dose by 25%.
Grade 2 (painful erythema, edema, or ulcers, but can eat): Delay dosing up to 2 weeks or until resolved to grade 0 or 1. If after 2 weeks there is no resolution, discontinue liposomal doxorubicin. If resolved to grade 0 or 1 within 2 weeks and no prior grade 3 or 4 stomatitis, continue treatment at previous dose. If prior grade 3 or 4 stomatitis, decrease dose by 25%.
Grade 3 (painful erythema, edema, or ulcers, and cannot eat): Delay dosing up to 2 weeks or until resolved to grade 0 or 1. Decrease dose by 25% and return to original dosing interval. If after 2 weeks there is no resolution, discontinue liposomal doxorubicin.
Grade 4 (requires parenteral or enteral support): Delay dosing up to 2 weeks or until resolved to grade 0 or 1. Decrease dose by 25% and return to original dosing interval. If after 2 weeks there is no resolution, discontinue liposomal doxorubicin.
Multiple myeloma (in combination with Bortezomib) (see Bortezomib monograph for bortezomib dosage reduction with toxicity guidelines):
Grade 3 or 4 nonhematologic toxicity: Delay dose until resolved to grade <2 and then reduce dose by 25%
Neuropathic pain or peripheral neuropathy: No dose reductions needed for doxorubicin liposomal, refer to Bortezomib monograph for bortezomib dosing adjustment.
Canadian labeling:
Hematologic toxicity:
Breast cancer, ovarian cancer: Refer to US dosage adjustment for hematologic toxicity section.
AIDS-related Kaposi sarcoma:
Grade 1 or grade 2 (ANC 1,500 to 1,900/mm3or platelets 75,000 to 150,000/mm3or ANC 1,000 to <1,500/mm3or platelets 50,000 to <75,000/mm3): No dosage adjustment necessary.
Grade 3 (ANC 500 to 999/mm3 and platelets 25,000 to <50,000/mm3): Delay treatment until ANC ≥1,000/mm3 and/or platelets ≥50,000/mm3 and then resume with a 25% dose reduction.
Grade 4 (ANC <500/mm3 and platelets <25,000/mm3): Delay treatment until ANC ≥1,000/mm3 and/or platelets ≥50,000/mm3 and then resume with a 50% dose reduction.
Nonhematologic toxicity:
Breast cancer, ovarian cancer:
Hand-foot syndrome (HFS; palmar-plantar erythrodysesthesia):
Grade 1 (mild erythema, swelling, or desquamation not interfering with daily activities): If at weeks 4 and 5 following prior dose, resume unless patients has experienced prior grade 3 or 4 HFS toxicity (if so, wait an additional week). If at week 6, decrease dose by 25%; return to 4-week interval.
Grade 2 (erythema, desquamation, or swelling interfering with, but not precluding, normal physical activities; small blisters or ulcerations <2 cm in diameter): If at weeks 4 and 5 following prior dose, wait an additional week. If at week 6, decrease dose by 25%; return to 4-week interval.
Grade 3 or grade 4 (blistering, ulceration, or swelling interfering with walking or normal daily activities; cannot wear regular clothing or diffuse or local process causing infectious complications, or a bedridden state or hospitalization): If at weeks 4 and 5 following prior dose, wait an additional week. If at week 6, discontinue therapy.
Stomatitis:
Grade 1 (painless ulcers, erythema, or mild soreness): If at weeks 4 and 5 following prior dose, resume unless patients has experienced prior grade 3 or 4 HFS toxicity (if so, wait an additional week). If at week 6, decrease dose by 25%; return to 4-week interval or discontinue therapy (based on physical assessment).
Grade 2 (painful erythema, edema, or ulcers, but can eat): If at weeks 4 and 5 following prior dose, wait an additional week. If at week 6, decrease dose by 25%; return to 4-week interval or discontinue therapy (based on physical assessment).
Grade 3 or grade 4 (painful erythema, edema, or ulcers, and cannot eat or requires parenteral or enteral support): If at weeks 4 and 5 following prior dose, wait an additional week. If at week 6, discontinue therapy.
AIDS-related Kaposi sarcoma:
Hand-foot syndrome (HFS; palmar-plantar erythrodysesthesia):
Grade 0 (no symptoms): If at week 3 or 4 following prior dose, redose at a 2-to 3-week interval.
Grade 1 (mild erythema, swelling, or desquamation not interfering with daily activities): If at week 3 following prior dose, resume unless patients has experienced prior grade 3 or 4 HFS toxicity (if so, wait an additional week). If at week 4 following prior dose, decrease dose by 25% and return to 3-week interval.
Grade 2 (erythema, desquamation, or swelling interfering with, but not precluding, normal physical activities; small blisters or ulcerations <2 cm in diameter): If at week 3 following prior dose, wait an additional week. If at week 4 following prior dose, decrease dose by 50% and return to 3-week interval.
Grade 3 or grade 4 (blistering, ulceration, or swelling interfering with walking or normal daily activities; cannot wear regular clothing, diffuse or local process causing infectious complications, or a bedridden state or hospitalization): If at week 3 following prior dose, wait an additional week. If at week 4, discontinue therapy.
Stomatitis:
Grade 1 (painless ulcers, erythema, or mild soreness): No dosage adjustment necessary.
Grade 2 (painful erythema, edema, or ulcers, but can eat): Wait 1 week and if symptoms improve, resume at 100% dose.
Grade 3 (painful erythema, edema, or ulcers, and cannot eat): Wait 1 week and if symptoms improve, resume with a 25% dose reduction.
Grade 4 (requires parenteral or enteral support): Wait 1 week and if symptoms improve, resume with a 50% dose reduction.
Dosing: Obesity
ASCO Guidelines for appropriate chemotherapy dosing in obese adults with cancer: Utilize patient’s actual body weight (full weight) for calculation of body surface area- or weight-based dosing, particularly when the intent of therapy is curative; manage regimen-related toxicities in the same manner as for nonobese patients; if a dose reduction is utilized due to toxicity, consider resumption of full weight-based dosing with subsequent cycles, especially if cause of toxicity (eg, hepatic or renal impairment) is resolved (Griggs 2012).
Reconstitution
Dilute doses ≤90 mg in D5W 250 mL prior to administration. Dilute doses >90 mg in D5W 500 mL. Solution is not clear, but has a red, translucent appearance due to the liposomal dispersion. Dilute ONLY in D5W; do not use bacteriostatic agents; do not mix with other medications.
Administration
IV: Monitor for infusion reaction. For IV infusion only; do not administer IV push. If contact with skin/mucosa occurs, wash immediately with soap and water.
Administer IVPB over 60 minutes; the manufacturer recommends infusing the first dose at initial rate of 1 mg/minute to minimize risk of infusion reactions; if no infusion-related reactions are observed, then increase the infusion rate for completion over 1 hour. Do NOT administer undiluted. Do NOT infuse with in-line filters. Do not mix with other medications. Monitor for local erythematous streaking along vein and/or facial flushing (may indicate rapid infusion rate).
For multiple myeloma, administer doxorubicin liposomal after bortezomib on day 4 of each cycle.
Irritant (Perez Fidalgo 2012); monitor infusion site; avoid extravasation. Assure proper needle or catheter position prior to administration.
Extravasation management: If extravasation, infiltration, or burning/stinging sensation occurs, stop infusion immediately and disconnect (leave cannula/needle in place); gently aspirate extravasated solution (do NOT flush the line); remove needle/cannula; elevate extremity (Perez Fidalgo 2012; Polovich 2009). Do not apply pressure to the site. Apply ice to the site for 15 minutes 4 times a day for 3 days.
Storage
Store intact vials refrigerated at 2°C to 8°C (36°F to 46°F); avoid freezing. Solutions diluted for infusion in D5W should be refrigerated at 2°C to 8°C (36°F to 46°F); administer within 24 hours.
Drug Interactions
Abiraterone Acetate: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Management: Avoid concurrent use of abiraterone with CYP2D6 substrates that have a narrow therapeutic index whenever possible. When concurrent use is not avoidable, monitor patients closely for signs/symptoms of toxicity. Consider therapy modification
Ado-Trastuzumab Emtansine: May enhance the cardiotoxic effect of Anthracyclines. Management: When possible, patients treated with ado-trastuzumab emtansine should avoid anthracycline-based therapy for up to 7 months after stopping ado-trastuzumab emtansine. Monitor closely for cardiac dysfunction in patients receiving this combination. Consider therapy modification
Ajmaline: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Aprepitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Asunaprevir: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Consider therapy modification
Baricitinib: Immunosuppressants may enhance the immunosuppressive effect of Baricitinib. Management: Use of baricitinib in combination with potent immunosuppressants such as azathioprine or cyclosporine is not recommended. Concurrent use with antirheumatic doses of methotrexate or nonbiologic disease modifying antirheumatic drugs (DMARDs) is permitted. Consider therapy modification
BCG (Intravesical): Immunosuppressants may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG (Intravesical): Myelosuppressive Agents may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
Bevacizumab: May enhance the cardiotoxic effect of Anthracyclines. Avoid combination
Bosentan: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Cardiac Glycosides: May diminish the cardiotoxic effect of Anthracyclines. Anthracyclines may decrease the serum concentration of Cardiac Glycosides. The effects of liposomal formulations may be unique from those of the free drug, as liposomal formulation have unique drug disposition and toxicity profiles, and liposomes themselves may alter digoxin absorption/distribution. Monitor therapy
Chloramphenicol (Ophthalmic): May enhance the adverse/toxic effect of Myelosuppressive Agents. Monitor therapy
Cladribine: May enhance the immunosuppressive effect of Immunosuppressants. Avoid combination
Cladribine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Avoid combination
CloBAZam: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Clofazimine: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
CloZAPine: Myelosuppressive Agents may enhance the adverse/toxic effect of CloZAPine. Specifically, the risk for neutropenia may be increased. Monitor therapy
Coccidioides immitis Skin Test: Immunosuppressants may diminish the diagnostic effect of Coccidioides immitis Skin Test. Monitor therapy
Conivaptan: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination
Cyclophosphamide: May enhance the cardiotoxic effect of Anthracyclines. Monitor therapy
CYP2D6 Inhibitors (Moderate): May decrease the metabolism of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
CYP2D6 Inhibitors (Strong): May decrease the metabolism of CYP2D6 Substrates (High risk with Inhibitors). Consider therapy modification
CYP3A4 Inducers (Moderate): May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
CYP3A4 Inducers (Strong): May increase the metabolism of CYP3A4 Substrates (High risk with Inducers). Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Consider therapy modification
CYP3A4 Inhibitors (Moderate): May decrease the metabolism of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
CYP3A4 Inhibitors (Strong): May decrease the metabolism of CYP3A4 Substrates (High risk with Inhibitors). Consider therapy modification
Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects). Consider therapy modification
Dacomitinib: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Management: Avoid concurrent use of dacomitinib with CYP2D6 subtrates that have a narrow therapeutic index. Consider therapy modification
Deferasirox: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Deferiprone: Myelosuppressive Agents may enhance the neutropenic effect of Deferiprone. Management: Avoid the concomitant use of deferiprone and myelosuppressive agents whenever possible. If this combination cannot be avoided, monitor the absolute neutrophil count more closely. Consider therapy modification
Denosumab: May enhance the adverse/toxic effect of Immunosuppressants. Specifically, the risk for serious infections may be increased. Monitor therapy
Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Specifically, the risk for agranulocytosis and pancytopenia may be increased Avoid combination
Duvelisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Echinacea: May diminish the therapeutic effect of Immunosuppressants. Consider therapy modification
Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Concurrent use of enzalutamide with CYP3A4 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring. Consider therapy modification
Erdafitinib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Erdafitinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Fam-Trastuzumab Deruxtecan: May enhance the cardiotoxic effect of Anthracyclines. Management: When possible, patients treated with fam-trastuzumab deruxtecan should avoid anthracycline-based therapy for up to 7 months after stopping fam-trastuzumab deruxtecan. Monitor closely for cardiac dysfunction in patients receiving this combination. Consider therapy modification
Fingolimod: Immunosuppressants may enhance the immunosuppressive effect of Fingolimod. Management: Avoid the concomitant use of fingolimod and other immunosuppressants when possible. If combined, monitor patients closely for additive immunosuppressant effects (eg, infections). Consider therapy modification
Fosaprepitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Fosnetupitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Fusidic Acid (Systemic): May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination
Idelalisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination
Imatinib: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Ivosidenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Larotrectinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Management: Consider not using a leflunomide loading dose in patients receiving other immunosuppressants. Patients receiving both leflunomide and another immunosuppressant should be monitored for bone marrow suppression at least monthly. Consider therapy modification
Lenograstim: Antineoplastic Agents may diminish the therapeutic effect of Lenograstim. Management: Avoid the use of lenograstim 24 hours before until 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Consider therapy modification
Lipegfilgrastim: Antineoplastic Agents may diminish the therapeutic effect of Lipegfilgrastim. Management: Avoid concomitant use of lipegfilgrastim and myelosuppressive cytotoxic chemotherapy. Lipegfilgrastim should be administered at least 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Consider therapy modification
Lorlatinib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Avoid concurrent use of lorlatinib with any CYP3A4 substrates for which a minimal decrease in serum concentrations of the CYP3A4 substrate could lead to therapeutic failure and serious clinical consequences. Consider therapy modification
Lumefantrine: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Mesalamine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
MiFEPRIStone: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Management: Minimize doses of CYP3A4 substrates, and monitor for increased concentrations/toxicity, during and 2 weeks following treatment with mifepristone. Avoid cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus. Consider therapy modification
Mitotane: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Consider therapy modification
Natalizumab: Immunosuppressants may enhance the adverse/toxic effect of Natalizumab. Specifically, the risk of concurrent infection may be increased. Avoid combination
Netupitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Nivolumab: Immunosuppressants may diminish the therapeutic effect of Nivolumab. Consider therapy modification
Ocrelizumab: May enhance the immunosuppressive effect of Immunosuppressants. Monitor therapy
Palbociclib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Palifermin: May enhance the adverse/toxic effect of Antineoplastic Agents. Specifically, the duration and severity of oral mucositis may be increased. Management: Do not administer palifermin within 24 hours before, during infusion of, or within 24 hours after administration of myelotoxic chemotherapy. Consider therapy modification
Panobinostat: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Peginterferon Alfa-2b: May decrease the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Peginterferon Alfa-2b may increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Pegloticase: May diminish the therapeutic effect of PEGylated Drug Products. Monitor therapy
Pegvaliase: PEGylated Drug Products may enhance the adverse/toxic effect of Pegvaliase. Specifically, the risk of anaphylaxis or hypersensitivity reactions may be increased. Monitor therapy
Pidotimod: Immunosuppressants may diminish the therapeutic effect of Pidotimod. Monitor therapy
Pimecrolimus: May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Promazine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
QuiNINE: May increase the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Monitor therapy
Roflumilast: May enhance the immunosuppressive effect of Immunosuppressants. Consider therapy modification
Sarilumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Siltuximab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Simeprevir: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Siponimod: Immunosuppressants may enhance the immunosuppressive effect of Siponimod. Monitor therapy
Sipuleucel-T: Immunosuppressants may diminish the therapeutic effect of Sipuleucel-T. Management: Evaluate patients to see if it is medically appropriate to reduce or discontinue therapy with immunosuppressants prior to initiating sipuleucel-T therapy. Consider therapy modification
Smallpox and Monkeypox Vaccine (Live): Immunosuppressants may diminish the therapeutic effect of Smallpox and Monkeypox Vaccine (Live). Monitor therapy
Stavudine: DOXOrubicin (Liposomal) may diminish the therapeutic effect of Stavudine. Monitor therapy
Stiripentol: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring. Consider therapy modification
Tacrolimus (Topical): May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Taxane Derivatives: May enhance the adverse/toxic effect of Anthracyclines. Taxane Derivatives may increase the serum concentration of Anthracyclines. Taxane Derivatives may also increase the formation of toxic anthracycline metabolites in heart tissue. Consider therapy modification
Tertomotide: Immunosuppressants may diminish the therapeutic effect of Tertomotide. Monitor therapy
Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy
Tofacitinib: Immunosuppressants may enhance the immunosuppressive effect of Tofacitinib. Management: Concurrent use with antirheumatic doses of methotrexate or nonbiologic disease modifying antirheumatic drugs (DMARDs) is permitted, and this warning seems particularly focused on more potent immunosuppressants. Consider therapy modification
Trastuzumab: May enhance the cardiotoxic effect of Anthracyclines. Management: When possible, patients treated with trastuzumab should avoid anthracycline-based therapy for up to 7 months after stopping trastuzumab. Monitor closely for cardiac dysfunction in patients receiving anthracyclines with trastuzumab. Consider therapy modification
Upadacitinib: Immunosuppressants may enhance the immunosuppressive effect of Upadacitinib. Avoid combination
Vaccines (Inactivated): Immunosuppressants may diminish the therapeutic effect of Vaccines (Inactivated). Management: Vaccine efficacy may be reduced. Complete all age-appropriate vaccinations at least 2 weeks prior to starting an immunosuppressant. If vaccinated during immunosuppressant therapy, revaccinate at least 3 months after immunosuppressant discontinuation. Consider therapy modification
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of Vaccines (Live). Immunosuppressants may diminish the therapeutic effect of Vaccines (Live). Management: Avoid use of live organism vaccines with immunosuppressants; live-attenuated vaccines should not be given for at least 3 months after immunosuppressants. Exceptions: Smallpox and Monkeypox Vaccine (Live). Avoid combination
Vinflunine: DOXOrubicin (Liposomal) may enhance the adverse/toxic effect of Vinflunine. Specifically, the risk for hematologic toxicities may be increased. DOXOrubicin (Liposomal) may increase the serum concentration of Vinflunine. Vinflunine may decrease the serum concentration of DOXOrubicin (Liposomal). Monitor therapy
Zidovudine: DOXOrubicin (Liposomal) may enhance the adverse/toxic effect of Zidovudine. DOXOrubicin (Liposomal) may diminish the therapeutic effect of Zidovudine. Consider therapy modification
Adverse Reactions
>10%:
Cardiovascular: Cardiomyopathy (≤11%)
Central nervous system: Fatigue (>20%), headache (1% to 11%)
Dermatologic: Palmar-plantar erythrodysesthesia (ovarian cancer: 51%), skin rash (ovarian cancer: 29%, Kaposi sarcoma: 1% to 5%), alopecia (ovarian cancer: 19%; Kaposi sarcoma: 9%)
Gastrointestinal: Nausea (ovarian cancer: 46%; Kaposi sarcoma: 17%), stomatitis (ovarian cancer: 41%; ovarian cancer, grades 3/4: 8%: Kaposi sarcoma: 7%), vomiting (ovarian cancer: 33%; Kaposi sarcoma: 8%), diarrhea (ovarian cancer: 21%; Kaposi sarcoma: 8%), constipation (>20%), anorexia (20%; Kaposi sarcoma: 1% to 5%), mucous membrane disease (ovarian cancer: 14%), dyspepsia (ovarian cancer: 12%)
Hematologic & oncologic: Thrombocytopenia (Kaposi sarcoma: grade 3: 61%, grade 4: 4%; ovarian cancer: grade 3: 1%), anemia (Kaposi sarcoma: grade 3: 55%, grade 4: 18%; grade 3: 5%, grade 4: <1%), neutropenia (Kaposi sarcoma: grade 3: 49%, grade 4: 13%; ovarian cancer: grade 3: 8%, grade 4: 4%)
Infection: Infection (1% to 12%)
Neuromuscular & skeletal: Asthenia (ovarian cancer: 40%; Kaposi sarcoma: 10%), back pain (1% to 12%)
Respiratory: Pharyngitis (ovarian cancer: 16%; Kaposi sarcoma: <1%), dyspnea (ovarian cancer: 15%; Kaposi sarcoma: 1% to 5%)
Miscellaneous: Fever (ovarian cancer: 21%; Kaposi sarcoma: 9%), infusion related reaction (7% to 11%)
1% to 10%:
Cardiovascular: Deep vein thrombosis (ovarian cancer: 1% to 10%), hypotension (1% to 10%), tachycardia (1% to 10%), vasodilation (ovarian cancer: 1% to 10%), chest pain (1% to 5%), peripheral edema (ovarian cancer: 1% to 5%)
Central nervous system: Depression (ovarian cancer: 1% to 10%), dizziness (1% to 10%), drowsiness (1% to 10%), anxiety (ovarian cancer: 1% to 5%), chills (1% to 5%), emotional lability (Kaposi sarcoma: 1% to 5%), insomnia (ovarian cancer: 1% to 5%), malaise (ovarian cancer: 1% to 5%)
Dermatologic: Acne vulgaris (ovarian cancer: 1% to 10%), ecchymoses (ovarian cancer: 1% to 10%), exfoliative dermatitis (ovarian cancer: 1% to 10%), fungal dermatitis (ovarian cancer: 1% to 10%), furunculosis (ovarian cancer: 1% to 10%), herpes simplex dermatitis (1% to 10%), maculopapular rash (ovarian cancer: 1% to 10%; Kaposi sarcoma: <1%), pruritus (1% to 10%), skin discoloration (ovarian cancer: 1% to 10%), vesiculobullous dermatitis (ovarian cancer: 1% to 10%), xeroderma (ovarian cancer: 1% to 10%), diaphoresis (ovarian cancer: 1% to 5%)
Endocrine & metabolic: Dehydration (ovarian cancer: 1% to 10%; Kaposi sarcoma: <1%), hypercalcemia (ovarian cancer: 1% to 10%), hypokalemia (ovarian cancer: 1% to 10%), hyponatremia (ovarian cancer: 1% to 10%), weight loss (1% to 10%), albuminuria (Kaposi sarcoma: 1% to 5%), hyperglycemia (Kaposi sarcoma: 1% to 5%), hypocalcemia (Kaposi sarcoma: 1% to 5%)
Gastrointestinal: Dysgeusia (ovarian cancer: 1% to 10%; Kaposi sarcoma: <1%), dysphagia (1% to 10%), esophagitis (ovarian cancer: 1% to 10%), intestinal obstruction (ovarian cancer: 1% to 10%), oral candidiasis (1% to 10%), oral mucosa ulcer (1% to 10%), abdominal pain (Kaposi sarcoma: 1% to 5%), aphthous stomatitis (Kaposi sarcoma: 1% to 5%), enlargement of abdomen (ovarian cancer 1% to 5%), glossitis (Kaposi sarcoma: 1% to 5%)
Genitourinary: Hematuria (ovarian cancer: 1% to 10%), urinary tract infection (ovarian cancer: 1% to 10%), vulvovaginal candidiasis (ovarian cancer: 1% to 10%)
Hematologic & oncologic: Rectal hemorrhage (ovarian cancer: 1% to 10%), hypochromic anemia (Kaposi sarcoma: ≥5%), hemolysis (Kaposi sarcoma: 1% to 5%), prolonged prothrombin time (Kaposi sarcoma: 1% to 5%)
Hepatic: Hyperbilirubinemia (1% to 10%), increased serum alkaline phosphatase (Kaposi sarcoma: 8%), increased serum alanine aminotransferase (Kaposi sarcoma: 1% to 5%)
Hypersensitivity: Hypersensitivity reaction (1% to 5%)
Infection: Herpes zoster infection (ovarian cancer: 1% to 10%; Kaposi sarcoma: <1%), paresthesia (5%), myalgia (ovarian cancer: 1% to 5%)
Ophthalmic: Conjunctivitis (ovarian cancer: 1% to 10%; Kaposi sarcoma: <1%), dry eye syndrome (ovarian cancer: 1% to 10%), retinitis (Kaposi sarcoma 1% to 5%)
Respiratory: Increased cough (ovarian cancer: 10%; Kaposi sarcoma: <1%), epistaxis (ovarian cancer: 1% to 10%), pneumonia (1% to 10%), rhinitis (ovarian cancer: 1% to 10%), sinusitis (ovarian cancer: 1% to 10%)
<1%: Bundle branch block, candidiasis, cardiac failure, cryptococcosis, hepatitis, palpitations, sepsis, thrombophlebitis, thrombosis, ventricular arrhythmia
Frequency not defined:
Hematologic & oncologic: Bone marrow depression, progression of cancer
Infection: Toxoplasmosis
Ophthalmic: Optic neuritis
Postmarketing: Erythema multiforme, lichenoid eruption (keratosis), muscle spasm, pulmonary embolism, secondary acute myelocytic leukemia, squamous cell carcinoma, Stevens-Johnson syndrome, toxic epidermal necrolysis
Warnings/Precautions
Concerns related to adverse effects:
- Bone marrow suppression: Neutropenia, anemia, and thrombocytopenia may occur. Monitor blood counts. Treatment delay, dosage modification, or discontinuation may be required. Hematologic toxicity may occur at a higher frequency and severity with combination chemotherapy.
- Cardiomyopathy: [US Boxed Warning]: Doxorubicin liposomal can cause myocardial damage (including acute left ventricular failure) as the total cumulative dose of doxorubicin approaches 550 mg/m2. The risk of cardiomyopathy was 11% when the cumulative anthracycline dose was between 450 and 550 mg/m2. Assess left ventricular cardiac function prior to, during, and after treatment. Cardiomyopathy is defined as a >20% decrease in resting left ventricular ejection fraction (LVEF) from baseline (if LVEF remained in the normal range) or a >10% decrease from baseline (where LVEF was less than the institutional lower limit of normal). Some patients developed signs/symptoms of heart failure without documented evidence of cardiomyopathy. The risk of cardiomyopathy with doxorubicin is generally proportional to the cumulative exposure; include prior use of other anthracyclines or anthracenediones in the calculations of the cumulative dose. The risk of cardiomyopathy may be increased at lower cumulative doses in patients with prior mediastinal irradiation. Assess left ventricular function with ECG or multigated acquisition scan prior to and during treatment to detect acute changes; monitor after treatment to detect delayed cardiotoxicity. Use in patients with a history of cardiovascular disease only if potential benefits outweigh cardiovascular risk.
- Infusion-related reactions: [US Boxed Warning]: Serious, life-threatening, and fatal infusion-related reactions can occur with doxorubicin (liposomal). Acute infusion-related reactions occurred in 11% of patients with solid tumors. Withhold doxorubicin (liposomal) for infusion-related reactions and resume at a reduced rate. Discontinue doxorubicin (liposomal) for serious or life-threatening infusion-related reactions. Infusion reactions may include flushing, shortness of breath, facial swelling, headache, chills, back pain, tightness in the chest or throat, hypotension, chest pain, pruritus, rash, cyanosis, syncope, tachycardia, bronchospasm, asthma, and apnea. Most reactions occurred during the first infusion. Some reactions have resulted in dose interruption. Medication and equipment to manage infusion reactions should be immediately available during infusion. Initiate infusion at a rate of 1 mg/minute, with the rate increased (to complete infusion over 60 minutes) as tolerated.
- Palmar-plantar erythrodysesthesia (hand-foot syndrome): Hand-foot syndrome has been reported in patients receiving doxorubicin liposomal. It is usually seen after 2 to 3 treatment cycles, although may also occur earlier. Dosage modification may be required; in severe or debilitating cases, treatment discontinuation may be required.
- Secondary malignancy: Cases of secondary oral cancers (primarily squamous cell carcinoma) have been reported with long-term (>1 year) doxorubicin liposomal exposure; these secondary oral malignancies have occurred during treatment and up to 6 years after treatment. The development of oral ulceration or discomfort should be monitored and further evaluated in patients with past or present use of doxorubicin liposomal. Tissue distribution of the liposomal doxorubicin compared to free doxorubicin may play a role in the development of oral secondary malignancies associated with long-term use.
Disease-related concerns:
- Hepatic impairment: Pharmacokinetics in patients with hepatic impairment have not been adequately studied. Doxorubicin is predominantly eliminated hepatically; reduce doxorubicin liposomal dose in patients with serum bilirubin ≥1.2 mg/dL.
Special populations:
- Splenectomized patients: Use in splenectomized patients with AIDS-related Kaposi sarcoma has not been studied and is not recommended (Canadian labeling [Caelyx]).
Concurrent drug therapy issues:
- Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.
Dosage form specific issues:
- Liposomal vs conventional formulation dosing: Liposomal formulations of doxorubicin should NOT be substituted for conventional doxorubicin hydrochloride on a mg-per-mg basis.
Monitoring Parameters
CBC with differential and platelet count, liver function tests (ALT/AST, bilirubin, alkaline phosphatase); monitor infusion site, monitor for infusion reactions, hand-foot syndrome, stomatitis, and oral ulceration/discomfort suggestive of secondary oral malignancy; pregnancy test (prior to treatment initiation in females of reproductive potential).
Cardiac function (left ventricular ejection fraction; baseline and periodic); ECG, or multigated acquisition scan may be used.
Pregnancy
Pregnancy Considerations
Based on the mechanism of action and data from animal reproduction studies, doxorubicin (liposomal) may cause fetal harm if administered during pregnancy. Use during the first trimester should be avoided.
Evaluate pregnancy status prior to use in females of reproductive potential. Women of reproductive potential and men with female partners of reproductive potential should use effective contraception during therapy and for 6 months after treatment. Doxorubicin liposomal may impair fertility in men and women. In men, doxorubicin may damage spermatozoa and testicular tissue, resulting in possible genetic fetal abnormalities; may also result in oligospermia, azoospermia, and permanent loss of fertility (sperm counts have been reported to return to normal levels in some men, occurring several years after the end of therapy). In females of reproductive potential, doxorubicin may cause infertility and result in amenorrhea; premature menopause can occur.
Patient Education
What is this drug used for?
- It is used to treat cancer.
Frequently reported side effects of this drug
- Constipation
- Diarrhea
- Abdominal pain
- Nausea
- Vomiting
- Lack of appetite
- Back pain
- Headache
- Hair loss
- Sore throat
- Weight loss
- Urine or body fluid discoloration
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
- Infection
- Blood clots like numbness or weakness on one side of the body; pain, redness, tenderness, warmth, or swelling in the arms or legs; change in color of an arm or leg; chest pain; shortness of breath; fast heartbeat; or coughing up blood
- Heart problems like cough or shortness of breath that is new or worse, swelling of the ankles or legs, abnormal heartbeat, weight gain of more than five pounds in 24 hours, dizziness, or passing out
- Infusion reaction like flushing, shortness of breath, wheezing, swelling in your throat, headache, chills, chest pain, back pain, chest or throat tightness, fast heartbeat, severe dizziness, passing out, or blue/gray skin discoloration
- Bleeding like vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a reason or that get bigger; or any severe or persistent bleeding
- Mouth sores
- Mouth pain
- Mouth ulcers
- Burning or numbness feeling
- Redness or irritation of palms or soles of feet
- Severe loss of strength and energy
- Severe injection site redness, burning, pain, swelling, or leaking of fluid
- Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.