7 Interactions found for:
- 3 Major
- 3 Moderate
- 1 Minor
Drug Interactions
Moderate
Benadryl
+ Hydroxyzine
The following applies to the ingredients: Diphenhydramine (found in Benadryl) and Hydroxyzine
Using diphenhydrAMINE together with hydrOXYzine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and Food Interactions
Moderate
Hydroxyzine
+ Food
The following applies to the ingredients: Hydroxyzine
Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with hydrOXYzine. Do not use more than the recommended dose of hydrOXYzine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate
Benadryl
+ Food
The following applies to the ingredients: Diphenhydramine (found in Benadryl)
Ask your doctor before using diphenhydrAMINE together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking diphenhydrAMINE. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and Pregnancy Interactions
Major
Hydroxyzine
+ Pregnancy
The following applies to the ingredients: Hydroxyzine
Professional Content
Use is contraindicated.
US FDA pregnancy category: Not Assigned.
Risk Summary: There are limited data available on use of this drug in early pregnancy to inform of a drug-related risk.
Comments:
-Some authorities state that use is contraindicated during early pregnancy.
-This drug crosses the placental barrier, which may lead to higher fetal than maternal concentrations.
-If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.
-Reports in neonates exposed during late pregnancy and/or labor and delivery included central nervous system (CNS) depression, clonic movements, extrapyramidal symptoms, hypotension, movement disorders, neonatal hypoxic conditions, and/or urinary retention.
Animal studies have revealed evidence of fetal abnormalities at doses substantially above the human therapeutic range. There are no controlled data in human pregnancy.
US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D and X are being phased out.
References
- "Product Information. Vistaril (hydroxyzine)." Pfizer U.S. Pharmaceuticals PROD (2001):
- "Product Information. Atarax (hydroxyzine)." Pfizer U.S. Pharmaceuticals PROD (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Minor
Benadryl
+ Pregnancy
The following applies to the ingredients: Diphenhydramine (found in Benadryl)
Professional Content
Use is recommended only if clearly needed and the benefit outweighs the risk.
AU TGA pregnancy category: A
US FDA pregnancy category: B
Comment:
-Exposure during the third trimester may result in adverse reactions in premature infants and neonates.
Animal models have failed to reveal evidence of impaired fertility or fetal harm at doses up to 5 times the human dose. There are no controlled data in human pregnancy.
AU TGA pregnancy category A: Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed.
US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
References
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis PROD (2002):
- "Product Information. Benadryl Children's Allergy Fastmelt (diphenhydrAMINE)." Pfizer U.S. Pharmaceuticals Group (2022):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. DiphenhydrAMINE Hydrochloride (diphenhydramine)." West-Ward Pharmaceuticals Corporation (previously Roxane Laboratories Inc) (2019):
Drug and Breastfeeding Interactions
Major
Benadryl
+ Breastfeeding
The following applies to the ingredients: Diphenhydramine (found in Benadryl)
Professional Content
Use is not recommended.
-According to some authorities: Use is contraindicated.
Excreted into human milk: Yes
Comments:
-The effects in the nursing infant are unknown.
-This drug may affect milk production, especially at high doses given early in the postpartum period and/or when used concomitantly with a sympathomimetic drug.
References
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis PROD (2002):
- "Product Information. Benadryl Children's Allergy Fastmelt (diphenhydrAMINE)." Pfizer U.S. Pharmaceuticals Group (2022):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013):
Major
Hydroxyzine
+ Breastfeeding
The following applies to the ingredients: Hydroxyzine
Professional Content
Use is not recommended, and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Excreted into human milk: Yes (cetirizine [main metabolite]); Unknown (parent drug)
Excreted into animal milk: No data (parent drug)
Comments:
-Some authorities state that use is contraindicated.
-This drug may be excreted into breast milk.
-Serious side effects have been reported in breastfed newborns/infants.
-Some experts state that healthcare providers should consider switching treatment to alternative agents (e.g., desloratadine, fexofenadine, loratadine), especially in breastfed newborn or preterm infants.
References
- "Product Information. Vistaril (hydroxyzine)." Pfizer U.S. Pharmaceuticals PROD (2001):
- "Product Information. Atarax (hydroxyzine)." Pfizer U.S. Pharmaceuticals PROD (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013):
- Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation." Philadelphia, PA: Wolters Kluwer Health (2015):
Therapeutic Duplication Warnings
Warning
Antihistamines
The following applies to: Benadryl (diphenhydramine), Hydroxyzine
Professional Content
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one. Your list includes two medicines.
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Switch to: Professional Interactions
| Drug Interaction Classification | |
|---|---|
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. |
|
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
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