3 Interactions found for:
Drug Interactions
A total of 660 medications are known to interact with mirtazapine. Add another medication to view potential interactions with this medication.
Drug and Food Interactions
Moderate
Mirtazapine
+ Food
The following applies to the ingredients: Mirtazapine
Alcohol can increase the nervous system side effects of mirtazapine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with mirtazapine. Do not use more than the recommended dose of mirtazapine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Drug and Pregnancy Interactions
Major
Mirtazapine
+ Pregnancy
The following applies to the ingredients: Mirtazapine
Professional Content
Use is not recommended unless clearly needed.
AU TGA pregnancy category: B3
US FDA pregnancy category: C
Comments:
-Use of adequate methods of contraception should be encouraged.
-If used during or shortly before birth, monitor newborn for discontinuation effects.
Animal models have revealed evidence of post-implantation loss, post-natal mortality, and reduced pup survival at twenty times the maximum recommended human dose (MRHD); these effects were not seen at 3 times the MRHD. Limited human data did not indicate increased risk of developmental toxicity. Epidemiological data suggest that selective serotonin receptor inhibitors may increase the risk of persistent pulmonary hypertension in the newborn, and this risk has not been ruled out for this drug.
AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
References
- "Product Information. Remeron (mirtazapine)." Organon PROD (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Drug and Breastfeeding Interactions
Major
Mirtazapine
+ Breastfeeding
The following applies to the ingredients: Mirtazapine
Professional Content
Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Excreted into human milk: Yes
Comments: Breastfed infants should be monitored for behavioral side effects and adequate growth.
A small study reported that after maternal doses between 30 to 120 mg, nursing infants received approximately 1.5% of the weight-adjusted maternal dose. Animal models showed an increase in postnatal mortality when dams were given doses of 100 mg/kg/day; no adequate and well-controlled studies exist for humans, though limited human data suggest a low risk of adverse effects, especially in infants older than 2 months of age.
References
- "Product Information. Remeron (mirtazapine)." Organon PROD (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013):
Therapeutic Duplication Warnings
No warnings were found for your selected drugs.Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Switch to: Professional Interactions
| Drug Interaction Classification | |
|---|---|
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. |
|
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
Disclaimer: This content should not be considered complete and should not be used in place of a call or visit to a healthcare professional. Use of this content is subject to our terms of use & medical disclaimer.