4 Interactions found for:
Drug Interactions
No drug interactions were found for selected drugs: pantoprazole, Vitamin C.
This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Drug and Food Interactions
No food interactions were found for selected drugs: pantoprazole, Vitamin C.
This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Drug and Pregnancy Interactions
Major
Pantoprazole
+ Pregnancy
The following applies to the ingredients: Pantoprazole
Professional Content
This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk.
-Some experts state that this drug should not be used in pregnancy.
AU TGA pregnancy category: B3
US FDA pregnancy category: Not assigned.
Risk summary: Observational studies indicate that an association of major malformations or adverse events with use of this drug during pregnancy; however, drug-associated risks cannot definitively be established or excluded by observational studies due to methodological limitations.
Animal models have revealed evidence of changes to femur bone length and weight when given during gestation day 6 through lactation day 21. There are no controlled data in human pregnancy.
AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.
US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.
References
- "Product Information. Protonix (pantoprazole)." Wyeth-Ayerst Laboratories PROD (2001):
- "Product Information. Protonix IV (pantoprazole)." Wyeth-Ayerst Laboratories PROD
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Minor
Vitamin C
+ Pregnancy
The following applies to the ingredients: Ascorbic Acid (found in Vitamin C)
Professional Content
Ascorbic acid has been assigned to pregnancy category A by the FDA when used in doses that are advocated by the FDA. Doses exceeding the recommended dietary allowance (RDA) have been assigned to pregnancy category C. Animal studies have not been reported. There are no controlled data in human pregnancy. Ascorbic acid is only recommended for use during pregnancy when benefit outweighs risk.
High doses of ascorbic acid taken during pregnancy have been reported to cause conditional scurvy in infants following birth.
References
- "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical PROD
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation." Philadelphia, PA: Lippincott Williams & Wilkins (2002):
Drug and Breastfeeding Interactions
Major
Pantoprazole
+ Breastfeeding
The following applies to the ingredients: Pantoprazole
Professional Content
Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Excreted into human milk: Yes (oral); Unknown (parenteral)
Excreted into animal milk: Yes (parenteral)
Comment: The effects in the nursing infant are unknown.
Animal models have evidence of decreased pup weight at doses of at least 10 mg/kg/day. There have been reports of excretion into human breast milk.
References
- "Product Information. Protonix (pantoprazole)." Wyeth-Ayerst Laboratories PROD (2001):
- "Product Information. Protonix IV (pantoprazole)." Wyeth-Ayerst Laboratories PROD
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013):
- Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation." Philadelphia, PA: Wolters Kluwer Health (2015):
Minor
Vitamin C
+ Breastfeeding
The following applies to the ingredients: Ascorbic Acid (found in Vitamin C)
Professional Content
Ascorbic acid is excreted into human breast milk. The effects in the nursing infant are unknown. The manufacturer recommends that caution be used when administering ascorbic acid to nursing women.
References
- "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical PROD
Therapeutic Duplication Warnings
No warnings were found for your selected drugs.Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Switch to: Professional Interactions
| Drug Interaction Classification | |
|---|---|
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. |
|
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
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